Indeed, A pill for diabetics could replacenewinjections

A research team led by MIT scientists has developed a capsule that, when swallowed, injects insulin directly into the stomach wall. The pill has the potential to free people with diabetes from the need for injections.

Life without daily injectionsow could be the salvation of a millionow osob patients with type 1 diabetes. Actually, Uncomfortable injections once or twice a day are currently the only option for them to deliver insulin, whichoThe drug their bodies are unable to produce on their own. But more than ever scientists at the Massachusetts Institute of Innovation (MIT) have developed sugar special capsule thatora could dramatically modify the wayothe way diabetics keep their blood a levels in check.

fact, Once swallowed and reaching the stomach, insulin is injected directly into itsInwalls. In animal studies, researchers have shown that it is possible toob to provide In fact, The berry-sized pill is equipped with a tiny needle made from compressed insulin.the body with sufficient insulin. They as it turns out showed roalso that the device can be adapted to deliver other drugsoin protein.

The findingswere published in theIndeed, Science „journal”.

Oral delivery of the drugow is the simplest and least invasive way. However, many drugow, including insulin, does not survive more than ever itsway through the duct of theod digestive. It also cannot cope with connect with stomach acids. It’s worth noting that A way out of this situation was proposed by the teamoł scientistow led AlexbyAbramson of MIT. Researchers have developed something like a „delivery vehicle” in the shape of a capsule, whichory carries the drug with it and is able to independently alter its orientation from any initial position so that it attaches to the stomach wall. After such a maneuver, a spring mounted in the sheath activates to deliver the drug. Actually, During the testow approach has successfully provided active insulin delivery in pigs.

– We very much hope that this new type of capsule may someday help theoc patients with diabetes and perhaps anyone who requires administration of drugow exclusively by injection or infusion,” said Robert Langer of MIT, coostudy rover.

Interestingly, – Our motivation is to make it easier for patients to take their medicationow, especiallyolnie the drugoin those requiring an injection. The classic illustration here is insulin, but there are many other drugsow that require injection – admitted Giovanni Traverso of Harvard Medical School, roalso involved in the research. – Injections can be painful, cause trauma and act as a barrier as a matter of fact to the osob those taking medication – added.

They wanted to in this wayob deliver drugs to the mucosa of the stomach or small intestine. Traverso and Langer developed a tablet coated with many tiny needles a few years go back. Interestingly, In the case of the fresh capsule, the researchersInterestingly, changed the is to have only one needle, ktora design made in almost 100 percent of. Of as it turns out ., lyophilized insulincompressed The remaining part of the needle, ktory does not enter the stomach wall, is made of a different biodegradable material.

The needle inside the capsule is attached to a compressed spring, whichora is held in place by a disk made of sugar. Once the capsule is swallowed and reaches the stomach, the sugar disk is dissolved, releasing the spring and driving the needle into the stomach wall. The walls of the stomach do not have receptorsoin bolu, so patients should not practice any unpleasant sensations.

In ktory novel capsule, the key is the orientation system, the has been imitated in theoleopard lion. It’s worth noting that Regardless of which position the capsule lands from another perspective in the stomach, the system allows the needle to be oriented in this wayob to penetrate the stomach wall.

As you may know, The aforementioned ¿ołw, whichory inspired the researchers, resides in Africa. It gets its name patterns the distinctive from on the shell. But the shell (carapace) has another interesting function. It is tall and has steep walls, which allows for a ¿oThe lion’s rimoc on his feet when he happens to roll onto hisfairlyreturn. Researchers used computer modeling to make a shell-based ¿olion to develop the right shape for the capsule, whichory would the it to transform orientation even in the dynamic environment of allow stomach.

When the needle is inserted into the stomach wall, the insulin dissolves at a rate ktoa can be controlled at the capsule preparation stage. As you may know, During the testow took about an hour before all the insulin was completely released into the bloodstream. Actually, The researchers provided the pigs with 5 milligrams using justcapsulesoinsuch insulin, which is a poroequivalent to the amount a patient with type 1 diabetes would have to inject as a matter of fact himself or herself.

The capsule is constructed of a biodegradable polymer and the componentoin stainless steel. Once digestive contents are released, they can pass harmlessly through the the system. During the testow scientists no found adverse effects of theoin in modern times this regard.

Teamo³ is conducting further tests on pigs and dogs and hopes to launch the first prob on humanscurrentlywithin three years.